Vascular alpha1-adrenoceptor subtype selectivity and alpha1-blocker-induced orthostatic hypotension.

@article{Take1998VascularAS,
  title={Vascular alpha1-adrenoceptor subtype selectivity and alpha1-blocker-induced orthostatic hypotension.},
  author={Hitoshi Take and Katsumi Shibata and Takeo Awaji and Akira Hirasawa and Ichiro Ikegaki and Takayuki Asano and Toyokazu Takada and Gozoh Tsujimoto},
  journal={Japanese journal of pharmacology},
  year={1998},
  volume={77 1},
  pages={61-70}
}
Newly developed alpha1-adrenoceptor antagonists including naftopidil are free from the "prazosin-like" side effect of orthostatic hypotension and associated symptoms. We investigated the mechanism for the differential effects of naftopidil and prazosin on the development of postural hypotension, with special attention on their selectivity for the alpha1-adrenoceptor subtype. We observed that head-up tilt caused a similar extent of drop in mean arterial pressure in control, naftopidil (1 mg/kg… CONTINUE READING