Vascular alpha 1D-adrenoceptors have a role in the pressor response to phenylephrine in the pithed rat.

@article{Zhou1996VascularA1,
  title={Vascular alpha 1D-adrenoceptors have a role in the pressor response to phenylephrine in the pithed rat.},
  author={Lin Zhou and Hugo M. Vargas},
  journal={European journal of pharmacology},
  year={1996},
  volume={305 1-3},
  pages={173-6}
}
In rats, the pressor response to intravenous (i.v.) phenylephrine is mediated by vascular alpha 1A- and alpha 1B-adrenoceptors, but the role of alpha 1D-adrenoceptors is uncertain. These studies evaluated the effect of a selective alpha 1D-adrenoceptor antagonist, BMY 7378 (8-[2-[4-(2- methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspirol[4,5]decane-7,9-dio ne 2HCl), on the pressor effect to i.v. phenylephrine (alpha 1A/B/D-adrenoceptor agonist) and (R)A-61603 (alpha 1A-adrenoceptor agonist; N-[5-(4… CONTINUE READING

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