Vascular aging in the longest‐living rodent, the naked mole‐rat

@article{Csiszar2007VascularAI,
  title={Vascular aging in the longest‐living rodent, the naked mole‐rat},
  author={Anna Csiszar and Nazar Labinskyy and Zsuzsanna Orosz and Rochelle Buffenstein and Zoltan I Ungvari},
  journal={The FASEB Journal},
  year={2007},
  volume={21}
}
Interspecies comparative assessment of vascular function among rodents with disparate longevity may offer insight into the mechanisms determining successful vascular aging. Previously we have shown that in shorter‐living mice and rats vascular aging is characterized by impaired endothelium‐dependent, nitric oxide‐mediated responses, oxidative stress and enhanced apoptotic cell death. The naked mole‐rat (NMR) is the longest‐living rodent known (maximum lifespan potential [MLSP]: >28 years). The… 

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And the beat goes on: maintained cardiovascular function during aging in the longest-lived rodent, the naked mole-rat.
TLDR
The naked mole-rat is the longest-lived rodent known, with a maximum lifespan potential (MLSP) of >31 years, and NMRs largely stave off cardiovascular changes for at least 75% of their MLSP, which suggests that using a comparative strategy to find factors that change with age in other mammals but not N MRs could provide novel targets to slow or prevent cardiovascular aging in humans.
Successful aging and sustained good health in the naked mole rat: a long-lived mammalian model for biogerontology and biomedical research.
TLDR
Surprisingly, NMRs have high levels of oxidative stress and relatively short telomeres, yet they are extremely resilient when subjected to cellular stressors and appear capable of sustaining both their genomic and protein integrity under hostile conditions.
Naked mole-rats maintain cardiac function and body composition well into their fourth decade of life
TLDR
Unlike mice, that manifest several aspects of human cardiac aging, NMRs maintain cardiac function and reserve capacity throughout their long lives and may offer insights on how to delay or prevent cardiac aging.
Slow Aging: Insights from an Exceptionally Long-Lived Rodent, the Naked Mole-Rat
TLDR
The challenge that lies ahead is to determine the mechanisms that facilitate the unusual profile associated with slow aging and prolonged health span in this rodent, and to test the ubiquity of these mechanisms in other species.
Negligible senescence in the longest living rodent, the naked mole-rat: insights from a successfully aging species
TLDR
The naked mole-rat may be the first reported mammal showing negligible senescence over the majority of their long lifespan, and clearly physiological and biochemical processes in this species have evolved to dramatically extend healthy lifespan.
Getting to the heart of the matter: age-related changes in diastolic heart function in the longest-lived rodent, the naked mole rat.
TLDR
Findings suggest that, notwithstanding the previously observed high lipid peroxidation in heart tissue, NMRs must possess mechanisms to stave off progression to fatal cardiac disease.
Hormones, reproduction and disease in the longest-lived rodent: the naked mole rat
TLDR
The aim of this review is to summarize knowledge on hormonal and reproductive aspects in NMR, and their resistance to pathological insults will be discussed.
Mechanisms of aging in the naked mole-rat: The case for programmed aging
TLDR
This premise that maximum species lifespan is indeed encoded in the genome is explored by reevaluating the various theories of aging in the light of what is known from the biology of the longest-living rodent, the naked mole-rat.
Naked mole-rats maintain healthy skeletal muscle and Complex IV mitochondrial enzyme function into old age
TLDR
It is reported that NMRs avoid sarcopenia for decades, and aged naked mole-rat skeletal muscle tissue contains some mitochondrial DNA rearrangements, although the common mitochondrial DNA deletions associated with aging in human and other rodent skeletal muscles are not present.
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