Vascular aging in the longest‐living rodent, the naked mole‐rat

  title={Vascular aging in the longest‐living rodent, the naked mole‐rat},
  author={Anna Csiszar and Nazar Labinskyy and Zsuzsanna Orosz and Rochelle Buffenstein and Zoltan I Ungvari},
  journal={The FASEB Journal},
Interspecies comparative assessment of vascular function among rodents with disparate longevity may offer insight into the mechanisms determining successful vascular aging. Previously we have shown that in shorter‐living mice and rats vascular aging is characterized by impaired endothelium‐dependent, nitric oxide‐mediated responses, oxidative stress and enhanced apoptotic cell death. The naked mole‐rat (NMR) is the longest‐living rodent known (maximum lifespan potential [MLSP]: >28 years). The… 

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And the beat goes on: maintained cardiovascular function during aging in the longest-lived rodent, the naked mole-rat.
The naked mole-rat is the longest-lived rodent known, with a maximum lifespan potential (MLSP) of >31 years, and NMRs largely stave off cardiovascular changes for at least 75% of their MLSP, which suggests that using a comparative strategy to find factors that change with age in other mammals but not N MRs could provide novel targets to slow or prevent cardiovascular aging in humans.
Successful aging and sustained good health in the naked mole rat: a long-lived mammalian model for biogerontology and biomedical research.
Surprisingly, NMRs have high levels of oxidative stress and relatively short telomeres, yet they are extremely resilient when subjected to cellular stressors and appear capable of sustaining both their genomic and protein integrity under hostile conditions.
Naked mole-rats maintain cardiac function and body composition well into their fourth decade of life
Unlike mice, that manifest several aspects of human cardiac aging, NMRs maintain cardiac function and reserve capacity throughout their long lives and may offer insights on how to delay or prevent cardiac aging.
Slow Aging: Insights from an Exceptionally Long-Lived Rodent, the Naked Mole-Rat
The challenge that lies ahead is to determine the mechanisms that facilitate the unusual profile associated with slow aging and prolonged health span in this rodent, and to test the ubiquity of these mechanisms in other species.
Negligible senescence in the longest living rodent, the naked mole-rat: insights from a successfully aging species
The naked mole-rat may be the first reported mammal showing negligible senescence over the majority of their long lifespan, and clearly physiological and biochemical processes in this species have evolved to dramatically extend healthy lifespan.
Getting to the heart of the matter: age-related changes in diastolic heart function in the longest-lived rodent, the naked mole rat.
Findings suggest that, notwithstanding the previously observed high lipid peroxidation in heart tissue, NMRs must possess mechanisms to stave off progression to fatal cardiac disease.
Hormones, reproduction and disease in the longest-lived rodent: the naked mole rat
The aim of this review is to summarize knowledge on hormonal and reproductive aspects in NMR, and their resistance to pathological insults will be discussed.
Mechanisms of aging in the naked mole-rat: The case for programmed aging
This premise that maximum species lifespan is indeed encoded in the genome is explored by reevaluating the various theories of aging in the light of what is known from the biology of the longest-living rodent, the naked mole-rat.
Naked mole-rats maintain healthy skeletal muscle and Complex IV mitochondrial enzyme function into old age
It is reported that NMRs avoid sarcopenia for decades, and aged naked mole-rat skeletal muscle tissue contains some mitochondrial DNA rearrangements, although the common mitochondrial DNA deletions associated with aging in human and other rodent skeletal muscles are not present.


The naked mole-rat: a new long-living model for human aging research.
  • R. Buffenstein
  • Biology
    The journals of gerontology. Series A, Biological sciences and medical sciences
  • 2005
Naked mole-rats are the longest-living (>28.3 years) rodents known and may provide a novel opportunity to examine mechanisms modulating aging, as well as potential use in aging research.
Comparison of endothelial function, O2.‐ and H2O2 production and vascular oxidative stress resistance between the longest‐living rodent, the naked mole‐rat and mice
Interspecies comparison showed that endothelial vasodilator function and vascular production of reactive oxygen species do not correlate with maximal lifespan, whereas increased lifespan potential is associated with an increased vascular resistance to pro‐apoptotic stimuli.
High oxidative damage levels in the longest‐living rodent, the naked mole‐rat
The findings strongly suggest that mechanisms other than attenuated oxidative stress explain the impressive longevity of the naked mole‐rat and that NMRs live an order of magnitude longer than predicted based on their body size.
Prolonged longevity in naked mole-rats: age-related changes in metabolism, body composition and gastrointestinal function.
Disparate patterns of age‐related changes in lipid peroxidation in long‐lived naked mole‐rats and shorter‐lived mice
Compared age‐related profiles of whole‐organism lipid peroxidation and liver lipid damage in long living naked mole‐rats and shorter‐living CB6F1 hybrid mice suggest that the pronounced longevity of naked Mole‐rats is independent of oxidative stress parameters.
Superoxide Excess in Hypertension and Aging: A Common Cause of Endothelial Dysfunction
O2− generation increases with age in WKY and is higher in SHRSP and may contribute to the reduced NO by scavenging and NAD(P)H oxidase may contributing to the age-related increase in O2−.
Aging-Induced Phenotypic Changes and Oxidative Stress Impair Coronary Arteriolar Function
Ageing induces changes in the phenotype of coronary arterioles that could contribute to the development of oxidative stress, which impairs NO-mediated dilations and forms peroxynitrite in A vessels.
Transcriptional basis for exercise limitation in male eNOS-knockout mice with age: heart failure and the fetal phenotype.
Age- and genotype-related exercise limitations in maximal work performed and maximal running distance in male eNOS-KO mice indicated that fetal phenotype and age were related to onset of heart failure.