Vascular adrenergic neuroeffector function does not decline in aged rats.

  title={Vascular adrenergic neuroeffector function does not decline in aged rats.},
  author={Sue Piper Duckles and Barrie J. Carter and Cynthia L. Williams},
  journal={Circulation research},
  volume={56 1},
To investigate adrenergic control of blood vessels during aging, rats aged 6, 12, 20, and 27 months were studied using in vitro techniques. Accumulation of [3H]norepinephrine, one index of adrenergic nerve density, did not alter with age in the femoral or renal arteries or renal vein. In the femoral vein [3H]norepinephrine accumulation was greater at 6 and 27 months of age. Norepinephrine sensitivity was determined in both an innervated vessel, the femoral artery, and a non-innervated vessel… CONTINUE READING


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