Vascular adhesion protein-1 blockade suppresses choroidal neovascularization.

  title={Vascular adhesion protein-1 blockade suppresses choroidal neovascularization.},
  author={Kousuke Noda and Haicheng She and Toru Nakazawa and Toshio Hisatomi and Shintaro Nakao and Lama Almulki and Souska Sophie Zandi and Shinsuke Miyahara and Yasuhiro Ito and Kennard L. Thomas and Rebecca C Garland and Joan W Miller and Evangelos S. Gragoudas and Yukihiko Mashima and Ali Hafezi-Moghadam},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={22 8},
Vascular adhesion protein-1 (VAP-1) is an endothelial cell adhesion molecule involved in leukocyte recruitment. Leukocytes and, in particular, macrophages play an important role in the development of choroidal neovascularization (CNV), an integral component of age-related macular degeneration (AMD). Previously, we showed a role for VAP-1 in ocular inflammation. Here, we investigate the expression of VAP-1 in the choroid and its role in CNV development. VAP-1 was expressed in the choroid… CONTINUE READING