Vascular Smooth Muscle Sirtuin-1 Protects Against Aortic Dissection During Angiotensin II–Induced Hypertension

@inproceedings{Fry2015VascularSM,
  title={Vascular Smooth Muscle Sirtuin-1 Protects Against Aortic Dissection During Angiotensin II–Induced Hypertension},
  author={Jessica L. Fry and Yasunaga Shiraishi and Rapha{\"e}l Turcotte and Xunjie Yu and Yuan Z. Gao and Rachid Akiki and Markus M Bachschmid and Yanhang Zhang and Kathleen G Morgan and Richard Alan Cohen and Francesca Seta},
  booktitle={Journal of the American Heart Association},
  year={2015}
}
BACKGROUND Sirtuin-1 (SirT1), a nicotinamide adenine dinucleotide(+)-dependent deacetylase, is a key enzyme in the cellular response to metabolic, inflammatory, and oxidative stresses; however, the role of endogenous SirT1 in the vasculature has not been fully elucidated. Our goal was to evaluate the role of vascular smooth muscle SirT1 in the physiological response of the aortic wall to angiotensin II, a potent hypertrophic, oxidant, and inflammatory stimulus. METHODS AND RESULTS Mice… CONTINUE READING
Highlighted Tweets
This paper has been referenced on Twitter 3 times. VIEW TWEETS

Citations

Publications citing this paper.
SHOWING 1-10 OF 16 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 37 REFERENCES