Vascular Permeability and Drug Delivery in Cancers

  title={Vascular Permeability and Drug Delivery in Cancers},
  author={Sandy Azzi and Jagoda K. Hebda and Julie Gavard},
  booktitle={Front. Oncol.},
The endothelial barrier strictly maintains vascular and tissue homeostasis, and therefore modulates many physiological processes such as angiogenesis, immune responses, and dynamic exchanges throughout organs. Consequently, alteration of this finely tuned function may have devastating consequences for the organism. This is particularly obvious in cancers, where a disorganized and leaky blood vessel network irrigates solid tumors. In this context, vascular permeability drives tumor-induced… CONTINUE READING