Vascular Pedicle Lengths After Hysterectomy: Toward Future Human Uterus Transplantation

  title={Vascular Pedicle Lengths After Hysterectomy: Toward Future Human Uterus Transplantation},
  author={Liza Johannesson and Cesar Diaz-Garcia and Henrik Leonhardt and Pernilla Dahm-K{\"a}hler and Janusz Marcickiewicz and Michael Olausson and Mats Br{\"a}nnstr{\"o}m},
  journal={Obstetrics \& Gynecology},
OBJECTIVE: To estimate uterine vessel lengths and diameters recovered at radical hysterectomy to assess prospects for direct vascular anastomosis bilaterally to the external iliacs in uterus transplantation, and thereby the feasibility of live uterus donation as a future treatment of absolute uterine factor infertility. METHODS: Patients (n=19; study group) undergoing radical hysterectomy for gynecologic malignancy participated. Preoperative magnetic resonance imaging (MRI) was performed in… 

Relationship between uterine veins, ureter, and hypogastric nerve for uterine transplantation: An anatomic study

The close relationship of the uterine veins with the ureter and the inferior hypogastric plexus is described, representing a surgical landmark to support the success of uterine transplantation by respecting both the graft and the safety of the living donor by limiting the risk of injuries during uterus procurement.

Uterine Autotransplantation in the Nonhuman Primate With Preservation of the Uterine and Ovarian Vascular Pedicles

This pilot study describes a modified surgical approach for uterine transplants in the nonhuman primate and suggests this surgical technique may be applicable to living and deceased donor uterine transplantation.

Human uterine vasculature with respect to uterus transplantation: A comprehensive review

Uterine arteries with/without anterior division of the internal iliac artery were the most frequent arteries used for inflow and produced the highest patency rate and the presence of atherosclerosis and complex arterial reconstruction was associated with a high rate of arterial thrombosis.

Assessment of an Alternative to the Uterine Vein for Venous Drainage in Human Uterine Transplantation: A Case Series Following Laparoscopic Hysterectomy

Uterine transplantation has become a viable option for women with absolute uterine factor infertility, however, this surgery requires extensive surgical dissection, and the surgical retrieval of the uterine vein proposes a challenge, presenting a potential option for venous drainage in uterine transplant surgery.

Analysis of Predictive Factors for Successful Vascular Anastomoses in a Sheep Uterine Transplantation Model

In order to perfect the management of vascular anastomoses by a vascular surgeon, training on animal models and in microsurgery are mandatory in establishing a uterine transplantation program in humans.

Evolution and Transformation of Uterine Transplantation: A Systematic Review of Surgical Techniques and Outcomes.

This systematic review of the available evidence of the surgical techniques and outcomes of UTx in terms of graft survival recommended specific surgical techniques that best yield a successful transplant and reduce complications for donors and recipients.

Imaging evaluation of uterine arteries in potential living donors for uterus transplantation: a comparative study of MRA, CTA, and DSA

MRI including MRA should be the initial modality to examine potential UTx donors to acquire valuable details of uterine anatomy, and if UAs are fully visualized, there is no need for further angiographic methods with radiation.



Fertility after autologous ovine uterine-tubal-ovarian transplantation by vascular anastomosis to the external iliac vessels.

This is the first report to demonstrate fertility and pregnancies going to term after autotransplantation of the uterus in an animal of a comparable size to the human.

Uterus transplantation in the baboon: methodology and long-term function after auto-transplantation.

This study demonstrates the feasibility of UTx by vascular anastomosis in a non-human primate species by developing surgical techniques for uterus retrieval and transplantation in the baboon.

A new surgical technique of uterine auto-transplantation in cynomolgus monkey: preliminary report about two cases

The feasibility of uterine auto-transplantation by using new surgical technique in cynomolgus monkeys is demonstrated by demonstrating there was no congestion in the uterus, and the uterus showed the typical red color of a normal uterus at 40 days after the operation.

Transplantation of the human uterus

  • W. FageehH. RaffaH. JabbadA. Marzouki
  • Medicine
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • 2002

Human Uterus Retrieval From a Multi-Organ Donor

The human uterus can be obtained from local organ donor networks using existing protocols and there are no signs of change over 12 hours of cold ischemia.

The Vascular Cast of the Human Uterus: From Anatomy to Physiology

The vascular border of supply between the uterine and ovarian arteries in postmenopausal women, which was positioned in the uterus 1‐2 cm from the tube, constitutes the first description of a functionally determined shift in the territorial divide of two vascular systems and has numerous practical implications.

Abdominal, vaginal and total laparoscopic hysterectomy: perioperative morbidity

VH ensures less complication rates than AH and in experienced centers, VH can be a reliable alternative to AH in controlled prospective studies with large patient volumes.

Successful uterine transplantation in the mouse: pregnancy and post-natal development of offspring.

These observations document the capacity of a transplanted uterus to harbour pregnancies to term, and reveal that offspring from a transplants uterus develop to normal fertile adults.