Vascular KCNQ potassium channels as novel targets for the control of mesenteric artery constriction by vasopressin, based on studies in single cells, pressurized arteries, and in vivo measurements of mesenteric vascular resistance.

@article{Mackie2008VascularKP,
  title={Vascular KCNQ potassium channels as novel targets for the control of mesenteric artery constriction by vasopressin, based on studies in single cells, pressurized arteries, and in vivo measurements of mesenteric vascular resistance.},
  author={Alexander Roy Mackie and Lioubov I. Brueggemann and Kyle K. Henderson and Aaron J Shiels and Leanne L. Cribbs and Karie E. Scrogin and Kenneth L Byron},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2008},
  volume={325 2},
  pages={475-83}
}
Pressor effects of the vasoconstrictor hormone arginine vasopressin (AVP), observed when systemic AVP concentrations are less than 100 pM, are important for the physiological maintenance of blood pressure, and they are also the basis for therapeutic use of vasopressin to restore blood pressure in hypotensive patients. However, the mechanisms by which circulating AVP induces arterial constriction are unclear. We examined the novel hypothesis that KCNQ potassium channels mediate the physiological… CONTINUE READING
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