Vascular Inflammation Is Negatively Autoregulated by Interaction Between CCAAT/Enhancer-Binding Protein- and Peroxisome Proliferator-Activated Receptor-

@inproceedings{Kitami2002VascularII,
  title={Vascular Inflammation Is Negatively Autoregulated by Interaction Between CCAAT/Enhancer-Binding Protein- and Peroxisome Proliferator-Activated Receptor-},
  author={Yutaka Kitami and Michitsugu Nakamura and Takafumi Okura},
  year={2002}
}
CCAAT/enhancer-binding proteins (C/EBPs) upregulate transcription of various inflammatory cytokines and acute phase proteins, such as interleukin (IL)-1 , IL-6, tumor necrosis factor, and cyclooxygenase-2. Recent studies have demonstrated that peroxisome proliferator–activated receptor (PPAR)is present in atherosclerotic lesions, and negatively regulates expression of these genes. Interestingly, PPARgene promoter has tandem repeats of C/EBP-binding motif, and C/EBPplays a pivotal role in… CONTINUE READING

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