Corpus ID: 82329454

Vascular Endothelial-cadherin plays a role in regulating the Norrin-FZD4 pathway and can cause Familial Exududative- vitroretinopathy (FEVR).

  title={Vascular Endothelial-cadherin plays a role in regulating the Norrin-FZD4 pathway and can cause Familial Exududative- vitroretinopathy (FEVR).},
  author={R. Amasheh},
FEVR is a genetic disorder that causes abnormal vascularization of the retina, which can lead to retinal detachment and blindness. Mutations in the genes encoding Norrin, LRP5, FZD4 and TSPAN12 can cause FEVR. Interestingly, these genes encode proteins that belong to the Norrin-FZD4 signalling pathway that ultimately activate β-catenin to upregulate gene transcription. Mutations in the pathway are thought to cause FEVR due to the lack of β-catenin translocating to the nucleus, however the… Expand

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