Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) Plays a Key Role in Vasculogenic Mimicry Formation, Neovascularization and Tumor Initiation by Glioma Stem-like Cells

@inproceedings{Yao2013VascularEG,
  title={Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) Plays a Key Role in Vasculogenic Mimicry Formation, Neovascularization and Tumor Initiation by Glioma Stem-like Cells},
  author={Xiaohong Yao and Yifang Ping and Ying Liu and Kequiang Chen and Teizo Yoshimura and Mingyong Liu and Wanghua Gong and Chong Chen and Qin Niu and Deyu Guo and Xia Zhang and Ji ming Wang and Xiu-Wu Bian},
  booktitle={PloS one},
  year={2013}
}
Human glioblastomas (GBM) are thought to be initiated by glioma stem-like cells (GSLCs). GSLCs also participate in tumor neovascularization by transdifferentiating into vascular endothelial cells. Here, we report a critical role of GSLCs in the formation of vasculogenic mimicry (VM), which defines channels lined by tumor cells to supply nutrients to early growing tumors and tumor initiation. GSLCs preferentially expressed vascular endothelial growth factor receptor-2 (VEGFR-2) that upon… CONTINUE READING
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