Vascular Endothelial Growth Factor-Induced Signaling Pathways in Endothelial Cells That Mediate Overexpression of the Chemokine IFN-γ-Inducible Protein of 10 kDa In Vitro and In Vivo

@inproceedings{Boulday2006VascularEG,
  title={Vascular Endothelial Growth Factor-Induced Signaling Pathways in Endothelial Cells That Mediate Overexpression of the Chemokine IFN-γ-Inducible Protein of 10 kDa In Vitro and In Vivo},
  author={Gw{\'e}nola Boulday and Zdenka H{\'a}skova and Marlies E J Reinders and Soumitro Pal and David Michael Briscoe},
  year={2006}
}
Vascular endothelial growth factor (VEGF), an angiogenesis factor, has recently been found to have potent proinflammatory properties in vivo. However, the mechanism by which it mediates inflammation is poorly understood. In this study, we have evaluated the function of VEGF on the induced expression and function of the T cell chemoattractant chemokine IFN-γ-inducible protein of 10 kDa (IP-10). In vitro, we find that VEGF augments the effect of IFN-γ on the induction of IP-10 mRNA and protein… CONTINUE READING

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