Vascular Endothelial Growth Factor C Promotes Lymph Node Metastasis in a Rectal Cancer Orthotopic Model

@article{Kawakami2004VascularEG,
  title={Vascular Endothelial Growth Factor C Promotes Lymph Node Metastasis in a Rectal Cancer Orthotopic Model},
  author={Masayo Kawakami and Yoshiyuki Kawano Keiji Yanai and Fumitake Hata and Koichi Hirata},
  journal={Surgery Today},
  year={2004},
  volume={35},
  pages={131-138}
}
Vascular endothelial growth factor C (VEGF-C), a novel member of the vascular endothelial growth factor family, is a relatively specific lymphangiogenic growth factor. It has been suggested that increased expression of VEGF-C in primary tumors is correlated with lymph node metastasis. We conducted this study to determine whether VEGF-C directly affects lymphangiogenesis and lymph node metastasis in colorectal cancer. For an accurate analysis and clear visualization of metastases, the rectal… CONTINUE READING