Vascular Effects of Ultrafine Particles in Persons with Type 2 Diabetes

  title={Vascular Effects of Ultrafine Particles in Persons with Type 2 Diabetes},
  author={Judith C. Stewart and David C. Chalupa and Robert B. Devlin and Lauren M. Frasier and Li-Shan Huang and Erika L. Little and Steven M. Lee and Richard P Phipps and Anthony P. Pietropaoli and Mark B. Taubman and Mark J. Utell and Mark W. Frampton},
  booktitle={Environmental health perspectives},
BACKGROUND Diabetes confers an increased risk for cardiovascular effects of airborne particles. OBJECTIVE We hypothesized that inhalation of elemental carbon ultrafine particles (UFP) would activate blood platelets and vascular endothelium in people with type 2 diabetes. METHODS In a randomized, double-blind, crossover trial, 19 subjects with type 2 diabetes inhaled filtered air or 50 µg/m³ elemental carbon UFP (count median diameter, 32 nm) by mouthpiece for 2 hr at rest. We repeatedly… CONTINUE READING


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