Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol.

  title={Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol.},
  author={Howard N. Hodis and Wendy J. Mack and Victor W. Henderson and Donna Shoupe and Matthew J. Budoff and Juliana Hwang-Levine and Yanjie Li and Mei Feng and Laurie Diane Dustin and Naoko Kono and Frank Z. Stanczyk and Robert H. Selzer and Stanley Paul Azen},
  journal={The New England journal of medicine},
  volume={374 13},
BACKGROUND Data suggest that estrogen-containing hormone therapy is associated with beneficial effects with regard to cardiovascular disease when the therapy is initiated temporally close to menopause but not when it is initiated later. However, the hypothesis that the cardiovascular effects of postmenopausal hormone therapy vary with the timing of therapy initiation (the hormone-timing hypothesis) has not been tested. METHODS A total of 643 healthy postmenopausal women were stratified… CONTINUE READING
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For personal use only. No other uses without permission. Copyright © 2016 Massachusetts Medical Society. All rights reserved. n engl j med 374;13 March • 2016

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