Effects of physical exercise on the P38MAPK/ REDD1/ 8 Motriz
- BL Pieri, DR Souza, TF Luciano, SO Marques, JR Pauli, AS Silva
- Rio Claro,
Cardiovascular disease (CVD) is the leading cause of mortality in the world and several risk factors for developing CVD have been pointed out, including obesity and physical inactivity. Endothelial dysfunction as a consequence of metabolic and inflammatory disorders plays an important role in the onset of vascular complications in obesity. In addition, it is well established that aerobic exercises promote beneficial effects on CVD by increasing nitric oxide (NO) production or its bioavailability in human and experimental models. The interest in exercise studies increased significantly, with promising results. Considering the importance of this field, the purpose of this mini-review is to summarize the animal studies that investigated the physiological mechanisms of vascular dysfunction in obesity and how aerobic exercise training influenced these alterations.