Vascular Damages in Rats Immunized by α1-Adrenoceptor Peptides

  title={Vascular Damages in Rats Immunized by α1-Adrenoceptor Peptides},
  author={Zihua Zhou and Yu-hua Liao and Liudong Li and Fen Wei and Bin Wang and Yumiao Wei and Min Wang and Xiang Cheng},
  journal={Cellular and Molecular Immunology},
Autoantibodies against the α1-adrenoceptor which had agonist activity as norepinephrine might play roles in the progression of hypertension, but whether the autoantibodies could induce vascular remodeling as norepinephrine is not clear. In this paper, the models with antibodies against the α1-adrenoceptor were made by immunizing Wistar rats with the synthesized the second extracellular loop of α1-adrenoceptor peptides. The homo-age male Wistar rats received BSA in the same immunizing manner and… CONTINUE READING


Publications referenced by this paper.
Showing 1-10 of 29 references

Autoantibodies against AT1-receptor and alpha1-adrenergic receptor in patients with hypertension.

Hypertension research : official journal of the Japanese Society of Hypertension • 2002
View 3 Excerpts

Small artery remodeling and significance in the development of hypertension.

News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society • 2002
View 1 Excerpt

: roles of apoptosis , inflammation , and fibrosis

SM Yu, SY Tsai, +3 authors JT Ou

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