Vascular Adaptation and Mechanical Homeostasis at Tissue, Cellular, and Sub-cellular Levels

@article{Humphrey2007VascularAA,
  title={Vascular Adaptation and Mechanical Homeostasis at Tissue, Cellular, and Sub-cellular Levels},
  author={J. Humphrey},
  journal={Cell Biochemistry and Biophysics},
  year={2007},
  volume={50},
  pages={53-78}
}
  • J. Humphrey
  • Published 2007
  • Biology, Medicine
  • Cell Biochemistry and Biophysics
  • Blood vessels exhibit a remarkable ability to adapt throughout life that depends upon genetic programming and well-orchestrated biochemical processes. Findings over the past four decades demonstrate, however, that the mechanical environment experienced by these vessels similarly plays a critical role in governing their adaptive responses. This article briefly reviews, as illustrative examples, six cases of tissue level growth and remodeling, and then reviews general observations at cell-matrix… CONTINUE READING
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