Vascular, glial and neuronal effects of vascular endothelial growth factor in mesencephalic explant cultures.

@article{Silverman1999VascularGA,
  title={Vascular, glial and neuronal effects of vascular endothelial growth factor in mesencephalic explant cultures.},
  author={William F. Silverman and Janette M Krum and N. K. Mani and Jeffrey M. Rosenstein},
  journal={Neuroscience},
  year={1999},
  volume={90 4},
  pages={1529-41}
}
Vascular endothelial growth factor is a highly conserved, heparin-binding protein which mediates a number of critical developmental processes in both vertebrates and invertebrates, including angiogenesis, vasculogenesis and hematopoiesis. We employed an organotypic rat explant model (produced from embryonic day 17 fetuses) to assess the effects of vascular endothelial growth factor on brain microvasculature in general and the ventral midbrain specifically. Immunohistochemistry using antisera to… CONTINUE READING