Varying levels of complexity in transcription factor binding motifs

  title={Varying levels of complexity in transcription factor binding motifs},
  author={Jens Keilwagen and Jan Grau},
  booktitle={Nucleic acids research},
Binding of transcription factors to DNA is one of the keystones of gene regulation. The existence of statistical dependencies between binding site positions is widely accepted, while their relevance for computational predictions has been debated. Building probabilistic models of binding sites that may capture dependencies is still challenging, since the most successful motif discovery approaches require numerical optimization techniques, which are not suited for selecting dependency structures… CONTINUE READING
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