Varying degrees of amplification of the N-ras oncogene in the human breast cancer cell line MCF-7.

@article{Graham1985VaryingDO,
  title={Varying degrees of amplification of the N-ras oncogene in the human breast cancer cell line MCF-7.},
  author={Kathryn E A Graham and Carol L. Richardson and Mark D Minden and Jeffrey M. Trent and Ronald N. Buick},
  journal={Cancer research},
  year={1985},
  volume={45 5},
  pages={2201-5}
}
The oncogene N-ras has been found to be amplified (congruent to 20 copies) in the human breast carcinoma cell line MCF-7. The amplified sequences have been localized to a marker chromosome by in situ hybridization. Sublines of MCF-7, serially passaged in different laboratories, have marked variation in the degree of N-ras amplification. The differing degrees of amplification of N-ras are further evidence of heterogeneity within MCF-7 subclones. The phenomenon may not have general relevance for… CONTINUE READING
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