Various polar tripeptides as asymmetric organocatalyst in direct aldol reactions in aqueous media.


A series of tripeptide organocatalysts containing a secondary amine group and two amino acids with polar side chain units were developed and evaluated in the direct asymmetric intermolecular aldol reaction of 4-nitrobenzaldehyde and cyclohexanone. The effectiveness of short polar peptides as asymmetric catalysts in aldol reactions to attain high yields of… (More)
DOI: 10.1002/chir.22205


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