Various V-J rearrangement efficiencies shape the mouse lambda B cell repertoire.

@article{Boudinot1995VariousVR,
  title={Various V-J rearrangement efficiencies shape the mouse lambda B cell repertoire.},
  author={Pierre Boudinot and Dominique Rueff-Juy and A M Drapier and Pierre Andr{\'e} Cazenave and Pierre Sanchez},
  journal={European journal of immunology},
  year={1995},
  volume={25 9},
  pages={2499-505}
}
The diversity of the B cell repertoire of C kappa knockout mice is limited by the expression of four lambda light chain types. Among the spleen B cells, lambda 1 is expressed by the majority (58%) of cells, and lambda 3 by the minority (8%), while lambda 2 (V2) and lambda 2 (Vx) are expressed in intermediate quantities (18% and 16%, respectively). To assess the influence of mechanistic pressures on the lambda subtype distribution, the proportions of the different lambda rearrangements were… CONTINUE READING