Variolins and related alkaloids.

  title={Variolins and related alkaloids.},
  author={Scott R Walker and Erin J Carter and Belinda C Huff and Jonathan C. Morris},
  journal={Chemical reviews},
  volume={109 7},
The phosphorylation of proteins on serine, threonine, and tyrosine residues by the 518 protein kinases encoded in the human genome constitutes one of the major mechanisms used by cells to regulate their metabolism and functions.1 The recent appreciation of the implication of abnormal protein phosphorylation in many human diseases has sparked considerable interest in the search for pharmacological inhibitors of kinases.2,3 
Highly Cited
This paper has 21 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 12 extracted citations


Publications referenced by this paper.
Showing 1-6 of 6 references

Anti-Cancer Drugs

  • E. Rossignol, A. Youssef, P. Moreau, M. Prudhomme, F. Anizon
  • Tetrahedron
  • 2007

Preparation of variolin derivatives for therapeutic use as antitumor agents

  • M. Remuinan, J. J. Gonzalez, +6 authors R. J. Anderson
  • 2003

Preparation of variolin B derivatives as antitumor agents

  • M. Alvarez, D. Fernandez Bleda, J. L. Fernandez Puentes
  • WO2002012240 A1,
  • 2002

Variolin Derivatives as Anti-Cancer Agents

  • R. J. Anderson, I. Manzanares, J. C. Morris, M. Remuiñán
  • WO0204447 A1,
  • 2002

For a review on the use of iminophosphoranes in azaWittig reactions for the synthesis of fused heterocycles

  • P. Molina, M. Vilaplana
  • J . Synthesis
  • 1994

The Madrid Protocol and its Relationship with the Antarctic Treaty System, Antarctic and Southern Oceans Law and Policy Occasional Paper

  • D. R. Rothwell
  • 1992

Similar Papers

Loading similar papers…