Variola virus immune evasion design: expression of a highly efficient inhibitor of human complement.

@article{Rosengard2002VariolaVI,
  title={Variola virus immune evasion design: expression of a highly efficient inhibitor of human complement.},
  author={Ariella M. Rosengard and Yu Liu and Zhiping Nie and Robert Jimenez},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 13},
  pages={8808-13}
}
Variola virus, the most virulent member of the genus Orthopoxvirus, specifically infects humans and has no other animal reservoir. Variola causes the contagious disease smallpox, which has a 30-40% mortality rate. Conversely, the prototype orthopoxvirus, vaccinia, causes no disease in immunocompetent humans and was used in the global eradication of smallpox, which ended in 1977. However, the threat of smallpox persists because clandestine stockpiles of variola still exist. Although variola and… CONTINUE READING
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