Variola minor in Braganca Paulista county, 1956: a trend-surface analysis.

@article{Angulo1977VariolaMI,
  title={Variola minor in Braganca Paulista county, 1956: a trend-surface analysis.},
  author={Juan J. Angulo and Peter Haggett and P Megale and A A Pederneiras},
  journal={American journal of epidemiology},
  year={1977},
  volume={105 3},
  pages={272-8}
}
Trend-surface analysis (TSA), a form of polynomial regression used in geology, ecology and geography, was applied to analysis of the spread of an epidemic of variola minor in a small Brazilian city. Cubic surfaces gave a generalized map of the space-time distribution of the epidemic, allowing those parts of the city to be identified where variola minor was spreading rapidly or slowly. The epidemic spread relatively quickly over the core area of the city, especially to the peripherally located… CONTINUE READING