Variety of Antiprion Compounds Discovered through an In Silico Screen Based on Cellular-Form Prion Protein Structure: Correlation between Antiprion Activity and Binding Affinity

@article{HosokawaMuto2008VarietyOA,
  title={Variety of Antiprion Compounds Discovered through an In Silico Screen Based on Cellular-Form Prion Protein Structure: Correlation between Antiprion Activity and Binding Affinity},
  author={Junji Hosokawa-Muto and Y. Kamatari and H. Nakamura and K. Kuwata},
  journal={Antimicrobial Agents and Chemotherapy},
  year={2008},
  volume={53},
  pages={765 - 771}
}
  • Junji Hosokawa-Muto, Y. Kamatari, +1 author K. Kuwata
  • Published 2008
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • ABSTRACT Transmissible spongiform encephalopathies are associated with the conformational conversion of the prion protein from the cellular form (PrPC) to the scrapie form. This process could be disrupted by stabilizing the PrPC conformation, using a specific ligand identified as a chemical chaperone. To discover such compounds, we employed an in silico screen that was based on the nuclear magnetic resonance structure of PrPC. In combination, we performed ex vivo screening using the Fukuoka-1… CONTINUE READING
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