Varied actions of proinflammatory cytokines on excitotoxic cell death in the rat central nervous system.


Interleukin (IL)-1beta mediates diverse forms of neurodegeneration and exacerbates cell death induced by striatal injection of the excitotoxin alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) in the rat brain. The objective of this study was to determine whether this effect was specific to IL-1beta. Injection of IL-1alpha and AMPA in the… (More)


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