Varicocele and Hypogonadism

@article{Dabaja2013VaricoceleAH,
  title={Varicocele and Hypogonadism},
  author={Ali A. Dabaja and Matthew S. Wosnitzer and Marc Goldstein},
  journal={Current Urology Reports},
  year={2013},
  volume={14},
  pages={309-314}
}
Accumulating evidence suggests that varicocele, long associated with male infertility, is also a risk factor for low testosterone levels. The exact pathophysiology of the negative effects of varicocele on testicular function is not well understood, but theories include venous stasis, increased testicular temperature, oxidative stress, and resulting toxic environment. While prior studies report conflicting effects of non-microsurgical varicocelectomy on testosterone level, recent literature… Expand
Varicoceles: prevalence and pathogenesis in adult men.
TLDR
The prevalence ofvaricocele in adults, the anatomic features of varicocele, the leading theories as to how varicoCele can negatively affect fertility potential, and the current literature on the impact of varICOcele on testosterone production are discussed. Expand
Endocrine Testing and the Association Between Varicocele and Hypogonadism
TLDR
New research indicates the correction of varicocele may also improve the function of Leydig cells, and, therefore, testosterone levels in hypogonadal men, and microsurgicalvaricocele repair may be offered to men with clinical varicoCele and Hypogonadism to improve their total serum testosterone. Expand
Reassessing the role of subclinical varicocele in infertile men with impaired semen quality: a prospective study.
TLDR
Significant improvement in the mean sperm concentration, total motility, and lower follicle-stimulating hormone levels was noted in those who underwent varicocele embolization as compared with those not treated. Expand
Microsurgical varicocelectomy for clinical varicocele: A review for potential new indications
TLDR
In conclusion, indications for microsurgical varicocelectomy may be extended by the concomitant right and left clinical varicocele and sexual dysfunction withvaricocele. Expand
Total Motile Sperm Count in Adolescent Boys with Varicocele is Associated with Hormone Levels and Total Testicular Volume.
TLDR
Optimize cutoffs for serum FSH, inhibinB, and TTV may prove to be a reasonable surrogates for TMSC in boys who defer SA for personal or religious/cultural reasons. Expand
Varicocele is associated with hypogonadism and impaired erectile function: a prospective comparative study
TLDR
The correlation of grade III and II varicocele with an increased risk of hypogonadism was confirmed in this study and an impaired erectile function correlated with TT levels and infertility duration was also observed. Expand
Editorial Comment from Dr Zampieri to Is the presence of varicocele associated with static and dynamic components of benign prostatic hyperplasia/lower urinary tract symptoms in elderly men?
  • N. Zampieri
  • Medicine
  • International journal of urology : official journal of the Japanese Urological Association
  • 2014
TLDR
Increased seminal reactive oxygen species levels in patients with varicoceles correlate withvaricocele grade but not with testis size, and prostate size correlates with fasting blood glucose in non-diabetic benign prostatic hyperplasia patients with normal testosterone levels. Expand
Does an Association between the Idiopathic Left-Sided Varicocele and Eye Colour Exist?
TLDR
The present results in adult men suggest that the prevalence of varicocele could be associated with the iris pigment, and the irIS pigmentation seems not to have a direct relationship with the sperm disturbances. Expand
The Prevalence and Association of Varicoceles on Male Patients With Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms.
TLDR
For elderly patients, the prevalence of varicocele shows an increasing trend with aging, and higher-grade varicoceles are associated with higher TPV and nocturia levels. Expand
The impact of coexisting sperm DNA fragmentation and seminal oxidative stress on the outcome of varicocelectomy in infertile patients: A prospective controlled study
TLDR
DFI% could be recommended as a prognostic test in infertile patients with varicocele to help decision-making as regards the necessity and the anticipated outcome of varicocelectomy in patients with infertility. Expand
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