Varicelloviruses avoid T cell recognition by UL49.5-mediated inactivation of the transporter associated with antigen processing.

@article{KoppersLalic2005VaricellovirusesAT,
  title={Varicelloviruses avoid T cell recognition by UL49.5-mediated inactivation of the transporter associated with antigen processing.},
  author={Danijela Koppers-Lalic and Eric A. J. Reits and Maaike E Ressing and Andrea D. Lipińska and Rupert Abele and Joachim Koch and Marisa Marcondes Rezende and Pieter C. Admiraal and Daphne van Leeuwen and Krystyna Bieńkowska-Szewczyk and Thomas C Mettenleiter and Frans A. M. Rijsewijk and Robert Tamp{\'e} and Jacques Neefjes and Emmanuel J H J Wiertz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 14},
  pages={5144-9}
}
Detection and elimination of virus-infected cells by cytotoxic T lymphocytes depends on recognition of virus-derived peptides presented by MHC class I molecules. A critical step in this process is the translocation of peptides from the cytoplasm into the endoplasmic reticulum by the transporter associated with antigen processing (TAP). Here, we identified the bovine herpesvirus 1-encoded UL49.5 protein as a potent inhibitor of TAP. The expression of UL49.5 results in down-regulation of MHC… CONTINUE READING

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