Varicella zoster virus vaccines: effective, but concerns linger.
@article{Liesegang2009VaricellaZV, title={Varicella zoster virus vaccines: effective, but concerns linger.}, author={Thomas J. Liesegang}, journal={Canadian journal of ophthalmology. Journal canadien d'ophtalmologie}, year={2009}, volume={44 4}, pages={ 379-84 } }
Both varicella and herpes zoster (HZ) can cause severe disease in certain age groups. The cell-mediated immune (CMI) response to the varicella zoster virus (VZV) is critical in preventing a recurrence of VZV. The varicella vaccine has markedly decreased the morbidity and mortality associated with varicella, but concerns linger about the cost and frequency of vaccine administration and the long-term effects on both adult varicella and HZ epidemiology in the individual and in the population…
27 Citations
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References
SHOWING 1-10 OF 63 REFERENCES
The effect of vaccination on the epidemiology of varicella zoster virus.
- Medicine, BiologyThe Journal of infection
- 2002
Targeted vaccination of susceptible adolescents and/or the contacts of high-risk individuals can be effective at preventing disease in these individuals with minimal risk to the community, but targeted strategies would not prevent most disease, and will not lead to a long-term reduction in the incidence of zoster.
Vaccination against Herpes Zoster and Postherpetic Neuralgia.
- MedicineThe Journal of infectious diseases
- 2008
The Shingles Prevention Study demonstrated that HZ vaccine significantly reduced the morbidity due to HZ and PHN in older adults.
Cost-Effectiveness of a Vaccine To Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults
- MedicineAnnals of Internal Medicine
- 2006
The Shingles Prevention Study examined whether vaccination with a live attenuated VZV vaccine would decrease the incidence and severity of herpes zoster and PHN in adults 60 years of age or older and performed an analysis of the cost-effectiveness of V ZV vaccination in immunocompetent older adults.
Exposure to varicella boosts immunity to herpes-zoster: implications for mass vaccination against chickenpox.
- MedicineVaccine
- 2002
Vaccination to prevent herpes zoster in older adults.
- MedicineThe journal of pain : official journal of the American Pain Society
- 2008
Clinical trials of varicella vaccine in healthy children.
- MedicineInfectious disease clinics of North America
- 1996
Epidemiology of varicella zoster virus infection in Canada and the United Kingdom
- MedicineEpidemiology and Infection
- 2001
A comprehensive picture of the pre-vaccine epidemiology of the varicella zoster virus (VZV) is provided to aid in the design of immunization programs and to adequately measure the impact of vaccination.
Effects of varicella vaccination on herpes zoster incidence.
- MedicineClinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
- 2004
An increase in zoster incidence after varicella immunisation is possible, but the extent is unknown because of the influence of other factors independent of immunisation.
Varicella Prevention in the United States: A Review of Successes and Challenges
- MedicinePediatrics
- 2008
Data are inconclusive regarding an effect of the varicella vaccination program on herpes zoster epidemiology; however, even with high vaccination coverage, the effectiveness of 1 dose of vaccine did not generate sufficient population immunity to prevent community transmission.
The incidence of zoster after immunization with live attenuated varicella vaccine. A study in children with leukemia. Varicella Vaccine Collaborative Study Group.
- MedicineThe New England journal of medicine
- 1991
In children with leukemia who receive the live attenuated varicella vaccine, the subsequent incidence of zoster is lower than in children who have naturalvaricella infections.