Varicella-zoster virus vaccine DNA differs from the parental virus DNA.

  title={Varicella-zoster virus vaccine DNA differs from the parental virus DNA.},
  author={Joseph R. Ecker and Richard Walter Hyman},
  journal={Journal of virology},
  volume={40 1},
The DNAs of a varicella-zoster virus vaccine and its parental virus were compared by CsCl buoyant density centrifugation and restriction enzyme cleavage analysis. The varicella-zoster virus vaccine DNA showed a heterogeneous buoyant profile and altered restriction enzyme cleavage patterns. These changed properties are probably the result of the accumulation of virus containing defective varicella-zoster virus DNA during extensive cell culture passage of the vaccine virus. 


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