Varicella-zoster virus infects human embryonic stem cell-derived neurons and neurospheres but not pluripotent embryonic stem cells or early progenitors.

@article{Dukhovny2012VaricellazosterVI,
  title={Varicella-zoster virus infects human embryonic stem cell-derived neurons and neurospheres but not pluripotent embryonic stem cells or early progenitors.},
  author={Anna Dukhovny and Anna Sloutskin and Amos Markus and Michael B. Yee and Paul R Kinchington and Ronald S Goldstein},
  journal={Journal of virology},
  year={2012},
  volume={86 6},
  pages={3211-8}
}
Pluripotent human stem cells are a powerful tool for the generation of differentiated cells that can be used for the study of human disease. We recently demonstrated that neurons derived from pluripotent human embryonic stem cells (hESC) can be infected by the highly host-restricted human alphaherpesvirus varicella-zoster virus (VZV), permitting the interaction of VZV with neurons to be readily evaluated in culture. In the present study, we examine whether pluripotent hESC and neural… CONTINUE READING
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