Varicella-zoster virus infection of adult rat sensory neurons in vitro.

  title={Varicella-zoster virus infection of adult rat sensory neurons in vitro.},
  author={M P Merville-Louis and Catherine Sadzot-Delvaux and P Delr{\'e}e and Jacques Piette and Gustave Moonen and Bernard Rentier},
  journal={Journal of virology},
  volume={63 7},
We report here an in vitro model of neuronal infection by varicella-zoster virus (VZV). Such a model has been achieved by using dissociated adult rat dorsal root ganglia cells infected by cocultivation with VZV-infected MRC5 cells or with cell-free virus. Indirect VZV immunolabeling, in situ hybridization, and neuron-specific immunolabeling demonstrated that VZV infection occurred selectively in neurons. VZV-specific immunolabeling detected a few neurons 1 or 2 days postinfection but not later… CONTINUE READING

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