Varicella zoster immune status in children treated for acute leukemia

@article{Patel2014VaricellaZI,
  title={Varicella zoster immune status in children treated for acute leukemia},
  author={Soonie R. Patel and Jessica M Bate and Peter A. C. Maple and Kevin E Brown and Judy Breuer and Paul T. Heath},
  journal={Pediatric Blood \& Cancer},
  year={2014},
  volume={61}
}
Children treated for acute leukemia are at increased risk of severe infection with varicella zoster virus (VZV). We studied the VZV sero‐status of children with acute leukemia prior to starting chemotherapy and after completion of chemotherapy. VZV sero‐status was assessed using time resolved fluorescence immunoassay (TRFIA) before starting treatment and 6 months after completion of treatment. Prior to starting treatment for acute leukemia, a significant proportion of children (35%) are VZV… 
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Varicella‐zoster virus infection in the pediatric population with acute lymphoblastic leukemia in Poland
TLDR
A low incidence of VZV infection was observed among pediatric patients with ALL in Poland between 2012 and 2019 years, and this analysis indicates that currently used therapeutic methods are effective in children with cancer and VzV infection.
Clinical characteristics and outcomes of varicella zoster virus infection in children with hematologic malignancies in the acyclovir era
TLDR
Clinical characteristics of VZV infection in immunocompromised children were not significantly different from those without it, and clinical outcomes improved after the introduction of acyclovir therapy, however, risk factors for severe VzV infection require further investigation in a larger population and a prospective setting.
The Impact of Chemotherapy after Pediatric Malignancy on Humoral Immunity to Vaccine-Preventable Diseases
TLDR
It is confirmed that seroprotection for vaccine-preventable diseases is affected by treatment for pediatric malignancy and a single booster dose of vaccine might be a practical way to restore vaccine immunity in patients after chemotherapy.
Progress in Treatment of Viral Infections in Children with Acute Lymphoblastic Leukemia
TLDR
Even though many patients with weakened immune system can benefit from progress in novel approaches, a viral infection still poses a very significant risk for many patients, so preventive measures and supportive care are very important for ALL patients.
Varicella in pediatric oncology patients in the post-vaccine era—Analysis of routine hospital data from Bavaria (Germany), 2005–2011
TLDR
Children with an ICD-10 main or secondary discharge diagnosis of varicella identified by annual database queries in Bavaria (Germany) in 2005–2011 potentially profit from herd protection effects, resulting from increasing vaccine coverage in the general population.
PEPtalk2: results of a pilot randomised controlled trial to compare VZIG and aciclovir as postexposure prophylaxis (PEP) against chickenpox in children with cancer
TLDR
The study identified factors that could be used to modify the design of a definitive trial but other options for defining the best means to protect such children against VZV should be explored.
Successful Prevention of Varicella Outbreak With Oral Aciclovir Following Party for Pediatric Oncology Patients.
TLDR
This research project aims to provide real-time information about the dynamic response of immune-inflammatory bowel disease in children aged five to eight years old through the use of a mobile imaging system.
Vaccination of patients with haematological malignancies who did not have transplantations: guidelines from the 2017 European Conference on Infections in Leukaemia (ECIL 7).
Developing World Perspective
Childhood ALL (cALL), the most common form of childhood cancer, is curable with ~90% becoming long term survivors using contemporary multi-agent chemotherapy. But there is a great disparity in…

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