Varicella-Zoster Virus Reactivation Is an Important Cause of Acute Peripheral Facial Paralysis in Children

  title={Varicella-Zoster Virus Reactivation Is an Important Cause of Acute Peripheral Facial Paralysis in Children},
  author={Yasushi Furuta and Fumio Ohtani and Hiroshi Aizawa and Satoshi Fukuda and Hiroki Kawabata and Tomas Bergström},
  journal={The Pediatric Infectious Disease Journal},
Background: Reactivation of herpes simplex virus type 1 is thought to be a major cause of adult idiopathic peripheral facial paralysis or Bell's palsy. However, few studies have examined the pathogenesis of this condition in children. Serologic assays and polymerase chain reaction (PCR) analysis of paired sera and saliva samples were used here to investigate the causes of acute peripheral facial paralysis in pediatric patients. Methods: A total of 30 children with acute peripheral facial… 
Reactivation of type 1 herpes simplex virus and varicella zoster virus in an immunosuppressed patient with acute peripheral facial weakness
Microbiologic Findings in Acute Facial Palsy in Children
Cerebrospinal fluid sampling is recommended for all pediatric cases in endemic areas, as cause was highly plausible in 67% and probable in an additional 11% of cases, and microbes associated with facial palsy could frequently be confirmed.
The association of Varicella zoster virus reactivation with Bell's palsy in children.
Are There Undiagnosed TBE-, Herpes- or Enteroviral Infections among Children Being Evaluated for Lyme Neuroborreliosis?
The results suggest that undiagnosed herpes- or enteroviral infections are unlikely to explain CNS symptoms in children being evaluated for LNB, whereas missed TBE infections may occur.
Search for varicella zoster virus DNA in saliva of healthy individuals aged 20–59 years
All neurological and ocular complications of varicella zoster virus (VZV) reactivation can occur without rash, and if VZV were readily detected in other tissue in patients with neurological disease without rash and found to correlate with tests listed above, more invasive tests such as lumbar puncture might be obviated.
Varicella-Zoster Virus Infections
Clinicians must be aware that VZV reactivation produces multiple disorders of the central nervous system (CNS) and peripheral nervous system, often without rash, so rapid virologic verification and prompt treatment with antiviral agents can lead to complete recovery, even in patients with protracted disease.
Varicella zoster virus infection
This Primer discusses the pathogenesis, diagnosis, treatment, and prevention of VZV infections, with an emphasis on the molecular events that regulate these diseases.


High prevalence of varicella-zoster virus reactivation in herpes simplex virus-seronegative patients with acute peripheral facial palsy.
VZV is one of the major etiologic agents of clinically diagnosed Bell's palsy and that VZV reactivation causes APFP in most patients who lack antibodies to HSV, according to serological assays and polymerase chain reaction analysis.
Serology in facial paralysis caused by clinically presumed herpes zoster infection
In some cases of peripheral facial palsy due to a clinically suspected varicella zoster virus (VZV) infection, the clinical diagnosis is not supported by serological tests, and evidence for a recent mumps virus infection was found in 6 patients and 1 patient was diagnosed as having recent mumped and cytomegalo-virus infections.
Herpes simplex virus in idiopathic facial paralysis (Bell palsy).
Sera from all 41 adult patients with idiopathic facil paralysis and 35 of 41 matched controls who had never had Bell palsy contained antibodies to herpes simplex virus, the only common factor among the patients tested in this study.
Detection of varicella‐zoster virus DNA in patients with acute peripheral facial palsy by the polymerase chain reaction, and its use for early diagnosis of zoster sine herpete
Results indicate that detection of VZV DNA in oropharyngeal swabs by PCR is more useful than currently available serological assays for the early diagnosis of zoster sine herpete in patients with APFP.
Variable patterns of varicella‐zoster virus reactivation in Ramsay hunt syndrome
The results indicate that facial paralysis in Ramsay Hunt syndrome can occur at various times between the early and the regression phase of VZV reactivation, suggesting that there are variable patterns of development of facial nerve dysfunction caused by V zoster reactivation and the progression of neuritis.
Reactivation of herpes simplex virus type 1 in patients with Bell's palsy
Findings strongly suggest that reactivation of HSV‐1 is involved in the pathogenesis of Bell's palsy, and indicate that PCR is a useful tool for early diagnosis of HSv‐1 reactivation in patients with Bell’s palsy.
Herpes Simplex Virus and Bell Palsy
  • J. Baringer
  • Medicine, Biology
    Annals of Internal Medicine
  • 1996
The inflammatory nature of the process has been suggested strongly by several recent papers on magnetic resonance imaging that indicate the frequent phenomenon of gadolinium-induced enhancement of the facial nerve in acute cases of Bell palsy.
Acute viral encephalitis in adults--a prospective study.
The study shows that HSV-1 was the most common etiological agent in patients with viral encephalitis in the Göteborg area, and in spite of improved diagnostic procedures, a large proportion of patients with symptoms and laboratory findings compatible with viralEncephalitis still have an unclear aetiology.
Bell's palsy and herpes simplex virus.
The possible association of some viral infections with the onset of Bell's palsy was examined in a study of 142 patients and a higher prevalence of herpes simplex virus (HSV) antibodies was found in the patient group with both a complement-fixation (CF) test and a radioimmunoassay (RIA).
Peripheral facial palsy and coincidental cytomegalovirus infection or reactivation.
Serological evidence of coincidental CMV multiplication in 72% of 65 consecutive cases with APFP is provided and transmission electron microscopy has revealed Herpetoviridae-like virus particles in 56% of urine samples studied.