Varicella-Zoster Virus Reactivation Is an Important Cause of Acute Peripheral Facial Paralysis in Children

  title={Varicella-Zoster Virus Reactivation Is an Important Cause of Acute Peripheral Facial Paralysis in Children},
  author={Yasushi Furuta and Fumio Ohtani and Hiroshi Aizawa and Satoshi Fukuda and Hiroki Kawabata and Tomas Bergström},
  journal={The Pediatric Infectious Disease Journal},
Background: Reactivation of herpes simplex virus type 1 is thought to be a major cause of adult idiopathic peripheral facial paralysis or Bell's palsy. However, few studies have examined the pathogenesis of this condition in children. Serologic assays and polymerase chain reaction (PCR) analysis of paired sera and saliva samples were used here to investigate the causes of acute peripheral facial paralysis in pediatric patients. Methods: A total of 30 children with acute peripheral facial… 
Reactivation of type 1 herpes simplex virus and varicella zoster virus in an immunosuppressed patient with acute peripheral facial weakness
Microbiologic Findings in Acute Facial Palsy in Children
Cerebrospinal fluid sampling is recommended for all pediatric cases in endemic areas, as cause was highly plausible in 67% and probable in an additional 11% of cases, and microbes associated with facial palsy could frequently be confirmed.
The association of Varicella zoster virus reactivation with Bell's palsy in children.
Varicella-zoster virus cns disease clinical features in ukrainian patients. prospective study.
The main clinical manifestations of the disease were ganglionitis and ganglioradiculoneuritis and another brain lesion like uveitis, encephalitis and vasculitis were observed also.
Clinical and molecular aspects of varicella zoster virus infection.
Analyses of viral nucleic acid and gene expression in latently infected human ganglia and in an animal model of varicella latency in primates are serving to determine the mechanism(s) of VZV reactivation with the aim of preventing reactivation and the clinical sequelae.
Mumps, Cervical Zoster, and Facial Paralysis: Coincidence or Association?
An 8-year-old girl simultaneously developed left peripheral facial paralysis, ipsilateral cervical herpes zoster, and bilateral mumps sialadenitis, and elevated anti-mumps and anti-varicella zoster virus IgM antibodies in serological testing indicated recent infection of mumps and reactivation of VZV.


High prevalence of varicella-zoster virus reactivation in herpes simplex virus-seronegative patients with acute peripheral facial palsy.
VZV is one of the major etiologic agents of clinically diagnosed Bell's palsy and that VZV reactivation causes APFP in most patients who lack antibodies to HSV, according to serological assays and polymerase chain reaction analysis.
Serology in facial paralysis caused by clinically presumed herpes zoster infection
In some cases of peripheral facial palsy due to a clinically suspected varicella zoster virus (VZV) infection, the clinical diagnosis is not supported by serological tests, and evidence for a recent mumps virus infection was found in 6 patients and 1 patient was diagnosed as having recent mumped and cytomegalo-virus infections.
Herpes simplex virus in idiopathic facial paralysis (Bell palsy).
Sera from all 41 adult patients with idiopathic facil paralysis and 35 of 41 matched controls who had never had Bell palsy contained antibodies to herpes simplex virus, the only common factor among the patients tested in this study.
Detection of varicella‐zoster virus DNA in patients with acute peripheral facial palsy by the polymerase chain reaction, and its use for early diagnosis of zoster sine herpete
Results indicate that detection of VZV DNA in oropharyngeal swabs by PCR is more useful than currently available serological assays for the early diagnosis of zoster sine herpete in patients with APFP.
Variable patterns of varicella‐zoster virus reactivation in Ramsay hunt syndrome
The results indicate that facial paralysis in Ramsay Hunt syndrome can occur at various times between the early and the regression phase of VZV reactivation, suggesting that there are variable patterns of development of facial nerve dysfunction caused by V zoster reactivation and the progression of neuritis.
Reactivation of herpes simplex virus type 1 in patients with Bell's palsy
Findings strongly suggest that reactivation of HSV‐1 is involved in the pathogenesis of Bell's palsy, and indicate that PCR is a useful tool for early diagnosis of HSv‐1 reactivation in patients with Bell’s palsy.
Herpes Simplex Virus and Bell Palsy
  • J. Baringer
  • Medicine, Biology
    Annals of Internal Medicine
  • 1996
The inflammatory nature of the process has been suggested strongly by several recent papers on magnetic resonance imaging that indicate the frequent phenomenon of gadolinium-induced enhancement of the facial nerve in acute cases of Bell palsy.
Acute viral encephalitis in adults--a prospective study.
The study shows that HSV-1 was the most common etiological agent in patients with viral encephalitis in the Göteborg area, and in spite of improved diagnostic procedures, a large proportion of patients with symptoms and laboratory findings compatible with viralEncephalitis still have an unclear aetiology.
Reactivation of varicella-zoster virus in facial palsy associated with infectious mononucleosis.
A patient is reported in whom serology showed reactivation of varicella-zoster virus as a cause of facial palsy associated with infectious mononucleosis.
Bell's palsy and herpes simplex virus.
The possible association of some viral infections with the onset of Bell's palsy was examined in a study of 142 patients and a higher prevalence of herpes simplex virus (HSV) antibodies was found in the patient group with both a complement-fixation (CF) test and a radioimmunoassay (RIA).