Corpus ID: 80553425

Varicella Zoster Infection Associated withPharmacological JAK-STAT Inhibition viaRuxolitinib in Myeloproliferative Diseases

@article{Aktimur2017VaricellaZI,
  title={Varicella Zoster Infection Associated withPharmacological JAK-STAT Inhibition viaRuxolitinib in Myeloproliferative Diseases},
  author={S. H. Aktimur and G. K. Akkoyunlu and U. Malkan and N. Demirel and M. Turğut and I. Haznedaroglu},
  journal={The Journal of medical research},
  year={2017},
  volume={1}
}
Ruxolitinib phosphate is an inhibitor drug of the JAK family of protein kinases. The results from two Phase III studies in myelofibrosis (COMFORT-I, COMFORT-II) demonstrate the effectiveness of Ruxolitinib in patients with primary myelofibrosis (MF), post-polycythemia vera myelofibrosis (PV-MF) and post-essential thrombocythemia myelofibrosis (ET-MF). On the other hand, Ruxolitinib affects several cytokines (IL1, IL6 and TNF-a) and other immune processes (dendritic cells function and T-cell… Expand
1 Citations
A provider's guide to primary myelofibrosis: pathophysiology, diagnosis, and management.
TLDR
What is known about the disease pathogenesis is outlined, an approach to reaching the diagnosis is discussed, the prognosis of myelofibrosis is reviewed, and current therapeutic strategies are detailed. Expand

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Ruxolitinib had to be discontinued due to the severity of the infection in 2 pts, while the others either had a dose reduction or no dose alteration, and has been linked to increased incidence of opportunistic and non-opportunistic infections. Expand
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The effect of RUX on PV-related symptoms and QoL measures in the RESPONSE trial was evaluated and it was found that the severity of pruritus and its interference on daily life improved with RUX. Expand
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TLDR
It is demonstrated that ruxolitinib significantly affects DC differentiation and function leading to impaired T-cell activation and the findings may also explain the outstanding anti-inflammatory and immunomodulating activity of JAK inhibitors currently used in the treatment of MF and autoimmune diseases. Expand
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