Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors

@article{Farrant2005VariationsOA,
  title={Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors},
  author={Mark Farrant and Zoltan Nusser},
  journal={Nature Reviews Neuroscience},
  year={2005},
  volume={6},
  pages={215-229}
}
The proper functioning of the adult mammalian brain relies on the orchestrated regulation of neural activity by a diverse population of GABA (γ-aminobutyric acid)-releasing neurons. Until recently, our appreciation of GABA-mediated inhibition focused predominantly on the GABAA (GABA type A) receptors located at synaptic contacts, which are activated in a transient or 'phasic' manner by GABA that is released from synaptic vesicles. However, there is growing evidence that low concentrations of… Expand
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