Variations on a theme: the alternate translocations in APL

@article{Redner2002VariationsOA,
  title={Variations on a theme: the alternate translocations in APL},
  author={Robin L. Redner},
  journal={Leukemia},
  year={2002},
  volume={16},
  pages={1927-1932}
}
The t(15;17)(q22;q21) translocation is tightly linked to the APL phenotype, and the resultant PML-RAR fusion can be demonstrated in 98% of APL cases. Rare variant translocations have been reported, the majority of which on detailed analysis represent cryptic PML-RAR fusions. However, a handful of APL cases have been described with different genotypes. These include the t(11;17)(q23;q21) that produces the PLZF-RAR fusion, t(5;17)(q35;q21) that forms NPM-RAR, t(11;17)(q13;q21) that generates NUMA… CONTINUE READING
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Acute promyelocytic leukemia t(5;17) fusion product NPM-RAR down-regulates AP-1 activity in the presence of ATRA

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