Variations of the bilirubin uridine-diphosphoglucuronosyl transferase 1A1 gene in healthy Taiwanese.

@article{Huang2000VariationsOT,
  title={Variations of the bilirubin uridine-diphosphoglucuronosyl transferase 1A1 gene in healthy Taiwanese.},
  author={C. S. Huang and G A Luo and Mei Ling Huang and Shih Chen Yu and Su Sheng Yang},
  journal={Pharmacogenetics},
  year={2000},
  volume={10 6},
  pages={539-44}
}
The activity of uridine-diphosphoglucuronosyl transferase 1 (UGT1) may influence the concentration of serum bilirubin. Because UGT1 is too labile to be measured with classical biochemical methods, we analysed the whole UGT1A1 gene in 290 healthy Taiwanese adults by using the polymerase chain reaction method, and investigated the relationship between UGT1A1 genotypes and serum bilirubin levels. The results showed that slightly more than 50% of the subjects had one or more variant sites in UGT1A1… CONTINUE READING