Variations of the ataxia telangiectasia mutated gene in patients with chronic lymphocytic leukemia lack substantial impact on progression-free survival and overall survival: a Cancer and Leukemia Group B study.

@article{Lozanski2012VariationsOT,
  title={Variations of the ataxia telangiectasia mutated gene in patients with chronic lymphocytic leukemia lack substantial impact on progression-free survival and overall survival: a Cancer and Leukemia Group B study.},
  author={Gerard Lozanski and Amy S. Ruppert and Nyla A. Heerema and Arletta Lozanski and David E. Lucas and Amber L Gordon and John G Gribben and Vicki a. Morrison and K. Manjunath Rai and Guido Marcucci and Richard A Larson and John C. Byrd},
  journal={Leukemia & lymphoma},
  year={2012},
  volume={53 9},
  pages={1743-8}
}
The impact of mutation of the ATM (ataxia telangiectasia mutated) gene in chronic lymphocytic leukemia (CLL) treatment outcome has not been examined. We studied ATM mutations in 73 patients treated with fludarabine and rituximab. ATM gene mutation analysis was performed using temperature gradient capillary electrophoresis. The impact of detected variants on… CONTINUE READING