Variations of X Chromosome Inactivation Occur in Early Passages of Female Human Embryonic Stem Cells

@inproceedings{Dvash2010VariationsOX,
  title={Variations of X Chromosome Inactivation Occur in Early Passages of Female Human Embryonic Stem Cells},
  author={Tamar Dvash and Neta Lavon and Guoping Fan},
  booktitle={PloS one},
  year={2010}
}
X chromosome inactivation (XCI) is a dosage compensation mechanism essential for embryonic development and cell physiology. Human embryonic stem cells (hESCs) derived from inner cell mass (ICM) of blastocyst stage embryos have been used as a model system to understand XCI initiation and maintenance. Previous studies of undifferentiated female hESCs at intermediate passages have shown three possible states of XCI; 1) cells in a pre-XCI state, 2) cells that already exhibit XCI, or 3) cells that… CONTINUE READING

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