Variations in tumor cell growth rates and metabolism with oxygen concentration, glucose concentration, and extracellular pH.

@article{Casciari1992VariationsIT,
  title={Variations in tumor cell growth rates and metabolism with oxygen concentration, glucose concentration, and extracellular pH.},
  author={Joseph J. Casciari and Stratis V. Sotirchos and Robert M. Sutherland},
  journal={Journal of cellular physiology},
  year={1992},
  volume={151 2},
  pages={386-94}
}
Tumors and multicellular tumor spheroids can develop gradients in oxygen concentration, glucose concentration, and extracellular pH as they grow. In order to calculate these gradients and assess their impact on tumor growth, it is necessary to quantify the effect of these variables on tumor cell metabolism and growth. In this work, the oxygen consumption rates, glucose consumption rates, and growth rates of EMT6/Ro mouse mammary tumor cells were measured at a variety of oxygen concentrations… CONTINUE READING
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