Variations in the vitamin D-binding protein (Gc locus) are associated with oral glucose tolerance in nondiabetic Pima Indians.

@article{Baier1998VariationsIT,
  title={Variations in the vitamin D-binding protein (Gc locus) are associated with oral glucose tolerance in nondiabetic Pima Indians.},
  author={Leslie J. Baier and Adam Dobberfuhl and Richard E. Pratley and Robert L Hanson and Clifton Bogardus},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1998},
  volume={83 8},
  pages={2993-6}
}
Electrophoretic variants of the vitamin D-binding protein (DBP) have been associated with type 2 diabetes as well as with metabolic characteristics that predispose to type 2 diabetes in several populations. The Gc gene that encodes DBP maps to chromosome 4q12, a region that has recently been found to be potentially linked to plasma glucose and insulin concentrations in Pima Indians. Therefore, the gene that encodes DBP was analyzed as a candidate gene for our linkage findings in the Pima… CONTINUE READING
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