Variations in the vitamin D-binding protein (Gc locus) and risk of type 2 diabetes mellitus in French Caucasians.

@article{Ye2001VariationsIT,
  title={Variations in the vitamin D-binding protein (Gc locus) and risk of type 2 diabetes mellitus in French Caucasians.},
  author={W Z Ye and Dani{\`e}le Dubois-Laforgue and Christine Bellann{\'e}-Chantelot and Jos{\'e} Timsit and Gilberto Velho},
  journal={Metabolism: clinical and experimental},
  year={2001},
  volume={50 3},
  pages={
          366-9
        }
}
Electrophoretic variants of the vitamin D-binding protein (DBP) have been reported to be associated with type 2 diabetes mellitus (DM) or with prediabetic phenotypes in several non-Caucasian populations. Two frequent missense polymorphisms at codons 416 (Asp --> Glu) and 420 (Thr --> Lys) are the genetic basis for the 3 common electrophoretic variants of DBP (Gc1F, Gc1S, and Gc2) and the resulting circulating phenotypes (Gc1F/Gc1F, Gc1F/Gc1S, Gc1S/Gc1S, Gc1F/Gc2, Gc1S/Gc2, and Gc2/Gc2). In this… CONTINUE READING

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