Variations in the multimerization region of the Helicobacter pylori cytotoxin CagA affect virulence.

  title={Variations in the multimerization region of the Helicobacter pylori cytotoxin CagA affect virulence.},
  author={D. B. Ahire and Tricia Alston and Robert D Raffaniello},
  journal={Oncology letters},
  volume={13 3},
Helicobacter pylori colonizes the human stomach by infecting gastric epithelial cells. It is the primary cause of peptic ulcer disease and gastric cancer (GC). Cytotoxin-associated gene A (CagA) is a virulence factor produced by H. pylori. Strains positive for the CagA protein are associated with more severe gastric diseases. The 3' region of the cagA gene exhibits heterogeneity with respect to tyrosine phosphorylation motifs (EPIYA) and CagA multimerization motifs (CM). CagA proteins are… 

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    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
  • 2010
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