Variations in the detection of ZAP-70 in chronic lymphocytic leukemia: Comparison with IgV(H) mutation analysis.

@article{Sheikholeslami2006VariationsIT,
  title={Variations in the detection of ZAP-70 in chronic lymphocytic leukemia: Comparison with IgV(H) mutation analysis.},
  author={Mohammad Reza Sheikholeslami and Iman B Jilani and Michael Keating and Jennifer Uyeji and K Chen and Hagop M Kantarjian and Susan M O'Brien and Francis J Giles and Maher Albitar},
  journal={Cytometry. Part B, Clinical cytometry},
  year={2006},
  volume={70 4},
  pages={270-5}
}
Lack of immunoglobulin heavy chain genes (IgV(H)) mutation in patients with chronic lymphocytic leukemia (CLL) is associated with rapid disease progression and shorter survival. The zeta-chain (T-cell receptor) associated protein kinase 70 kDa (ZAP-70) has been reported to be a surrogate marker for IgV(H) mutation status, and its expression in leukemic… CONTINUE READING