Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma

@article{Hasegawa2004VariationsIT,
  title={Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma},
  author={Koichi Hasegawa and Mayumi Tamari and Chenchen Shao and Makiko Shimizu and Naomi Takahashi and Xiao-quan Mao and Akiko Yamasaki and Fumiaki Kamada and Satoru Doi and Hiroshi Fujiwara and Akihiko Miyatake and Kimie Fujita and Gen Tamura and Yoichi Matsubara and Taro Shirakawa and Y. Suzuki},
  journal={Human Genetics},
  year={2004},
  volume={115},
  pages={295-301}
}
Bronchial asthma (BA) is a common chronic inflammatory disease characterized by hyperresponsive airways, excess mucus production, eosinophil activation, and the production of IgE. The complement system plays an immunoregulatory role at the interface of innate and acquired immunities. Recent studies have provided evidence that C3, C3a receptor, and C5 are linked to airway hyperresponsiveness. To determine whether genetic variations in the genes of the complement system affect susceptibility to… CONTINUE READING