Variations in peptide YY and Y2 receptor genes are associated with severe obesity in Pima Indian men.

@article{Ma2005VariationsIP,
  title={Variations in peptide YY and Y2 receptor genes are associated with severe obesity in Pima Indian men.},
  author={Lijun Ma and Pietro Antonio Tataranni and Robert L Hanson and Aniello M. Infante and Sayuko Kobes and Clifton Bogardus and Leslie J. Baier},
  journal={Diabetes},
  year={2005},
  volume={54 5},
  pages={1598-602}
}
Peptide YY (PYY) and Y2 receptor (Y2R) may be important in the central regulation of body weight and food intake. To determine whether genetic variation in PYY and/or Y2R may contribute to morbid obesity in humans, these genes were sequenced in 83 extremely obese Pima Indians (BMI > or = 50 kg/m2). Sequencing of PYY identified three single nucleotide polymorphisms (SNPs) in the untranslated region. Sequencing of the Y2R coding region identified one missense (Ala172Thr) substitution and two… CONTINUE READING